Design of a Screening Tool for the Early Detection of Polycystic Ovary Syndrome (PCOS)

Authors

  • Karla Yelena Moreno Hernández Universidad de la Salud del Estado de Puebla, Puebla México https://orcid.org/0009-0005-1877-7066
  • Heidi Alelia Morales Rojas Universidad de la Salud del Estado de Puebla, Puebla México https://orcid.org/0009-0005-0637-9765
  • Denisse Cruz Trejo Universidad de la Salud del Estado de Puebla, Puebla México https://orcid.org/0009-0001-8947-3802
  • Yessica Ibelith Cosme Herrera Universidad de la Salud del Estado de Puebla, Puebla México

DOI:

https://doi.org/10.56200/mentor.v5i2.12364

Keywords:

Polycystic ovary syndrome, health education, neuroendocrine axis, screening, women of chilbearing age

Abstract

According to the 2023 International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome (PCOS), the diagnosis in adult women is established by the presence of two of three criteria: clinical or biochemical hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology, with contextual incorporation of anti-Müllerian hormone in appropriate scenarios. The objective of the study was to design a screening instrument for the early detection of polycystic ovary syndrome in women of reproductive age. Based on this, a literature review was conducted following PRISMA 2020, including studies published between 2022 and 2026. A total of 33 scientific articles were selected to support the design of a preliminary screening instrument structured into six sections: general and anthropometric data, sociodemographic and clinical history, menstrual and reproductive history, clinical hyperandrogenism, nutrition and dietary habits, and emotional health. The resulting proposal integrates relevant reproductive, metabolic, and psychosocial dimensions for the initial identification of clinical patterns suggestive of PCOS. However, since the instrument is in a preliminary design phase, its interpretation should be considered exploratory and requires further validation prior to broader clinical or community implementation.

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Author Biographies

Karla Yelena Moreno Hernández, Universidad de la Salud del Estado de Puebla, Puebla México

Universidad de la Salud del Estado de Puebla, Puebla México

Heidi Alelia Morales Rojas, Universidad de la Salud del Estado de Puebla, Puebla México

Universidad de la Salud del Estado de Puebla, Puebla México

Denisse Cruz Trejo, Universidad de la Salud del Estado de Puebla, Puebla México

Universidad de la Salud del Estado de Puebla, Puebla México

Yessica Ibelith Cosme Herrera, Universidad de la Salud del Estado de Puebla, Puebla México

Universidad de la Salud del Estado de Puebla, Puebla México

References

Abruzzese, G. A., Velazquez, M. E., Cerrone, G. E., & Motta, A. B. (2023). Polycystic ovary syndrome in Latin American populations: What is known and what remains unresolved. Journal of Steroid Biochemistry and Molecular Biology, 225, 106195. https://doi.org/10.1016/j.jsbmb.2022.106195

Adashi, E. Y., Cibula, D., Peterson, M., & Azziz, R. (2023). The polycystic ovary syndrome: The first 150 years of study. F&S Reports, 4(1), 2–18. https://doi.org/10.1016/j.xfre.2022.12.002

Ali, Z., Vasavan, T., Meeladah, G., Eliza, W., Getreu, N., & O’Neill, H. (2022). P-738: Impact of limited reproductive health awareness on PCOS diagnosis timelines and the need for improved patient education. Human Reproduction, 37(Supplement_1). https://doi.org/10.1093/humrep/deac107.684

Amiri, M., Hatoum, S., Buyalos, R. P., Sheidaei, A., & Azziz, R. (2025). The influence of study quality, age, and geographic factors on PCOS prevalence: A systematic review and meta-analysis. The Journal of Clinical Endocrinology & Metabolism, 110(7), 2082–2103. https://doi.org/10.1210/clinem/dgae917

Atmaca, L., Chauhan, S., Najaf, S. S., Elmadani, M., Al-Jawarneh, M., Soloh, A., Varga, Z., Vitrai, J., & Prémusz, V. (2025). Effectiveness of exercise interventions on androgen and sex hormone-binding globulin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis. Frontiers in Sports and Active Living, 7, 1686566. https://doi.org/10.3389/fspor.2025.1686566

Baculescu, N., Radian, Ș., Manda, D., Serban, C. G., Niculescu, D. A., Gheorghiu, M. L., Grigorescu, F., & Poiana, C. (2025). Stimulated hyperinsulinemia is independently associated with higher serum DHEAS in PCOS: A retrospective study. Journal of Clinical Medicine, 14(17), 6246. https://doi.org/10.3390/jcm14176246

Barrea, L., Verde, L., Camajani, E., Cernea, S., Frias-Toral, E., Lamabadusuriya, D., Ceriani, F., Savastano, S., Colao, A., & Muscogiuri, G. (2023). Correction: Ketogenic diet as medical prescription in women with polycystic ovary syndrome (PCOS). Current Nutrition Reports, 12(1), 65. https://doi.org/10.1007/s13668-023-00463-2

Basak, S., Dixit, A. K., Dey, R. K., Puia, L., Bora, M., Kumar, S. Y. R., & Babu, G. (2025). An endocrinological perspective on polycystic ovarian syndrome. Molecular and Cellular Endocrinology, 602, 112524. https://doi.org/10.1016/j.mce.2025.112524

Bedrick, B. S., Eskew, A. M., Chavarro, J. E., & Jungheim, E. S. (2020). Self-administered questionnaire to screen for polycystic ovary syndrome. Women’s Health Reports, 1(1). https://doi.org/10.1089/whr.2020.0073

Begum, A. A., Raguthu, M., & Duvall-Ingram, A. (2026). Pre-screening questionnaire to identify polycystic ovary syndrome in primary care. The Journal for Nurse Practitioners, 22(2), 105644. https://doi.org/10.1016/j.nurpra.2025.105644

Bertani, N., Alteri, A., Cacciottola, L., et al. (2026). TGF-β signaling in the pathophysiology of the ovary: A double-edged regulator. Biomolecules, 16(1), 130. https://doi.org/10.3390/biom16010130

Cai, M., Ni, Z., Yuan, Z., Yu, J., Zhang, D., Yao, R., Zhou, L., & Yu, C. (2023). Past and present: A bibliometric study on polycystic ovary syndrome. Journal of Ovarian Research, 16(1), 42. https://doi.org/10.1186/s13048-022-01072-3

Calva-Rodríguez, R. G., & Sánchez-Rodríguez, G. (2025). Datos históricos de la salud pública en el estado de Puebla, México (1934–2024). Revista Mexicana de Pediatría, 92(2), 72–76. https://doi.org/10.35366/121153

Castro Torres, G. R., Rojas Mendoza, K. J., & Min Kim, H. (2023). Actualización sobre el síndrome de ovario poliquístico. Revista Médica Sinergia, 8(2), e968. https://doi.org/10.31434/rms.v8i2.968

Chang, K.-J., Chen, J.-H., & Chen, K.-H. (2024). The pathophysiological mechanism and clinical treatment of polycystic ovary syndrome: A molecular and cellular review of the literature. International Journal of Molecular Sciences, 25(16). https://doi.org/10.3390/ijms25169037

Chen, Y., Sun, X., Xia, X., Chen, K., & Zeng, F. (2025). The pathogenesis, therapeutic targets and drugs of polycystic ovary syndrome. Frontiers in Endocrinology, 16, 1722649. https://doi.org/10.3389/fendo.2025.1722649

Chen, Y., Zhang, Q., Ma, J., & Yu, Y. (2022). Mapping research trends of insulin resistance in polycystic ovary syndrome from 2017 to 2021: A bibliometric analysis. Frontiers in Endocrinology, 13, 963213. https://doi.org/10.3389/fendo.2022.963213

Corrie, L., Awasthi, A., Kaur, J., Vishwas, S., Gulati, M., Kaur, I. P., Gupta, G., Kommineni, N., Dua, K., & Singh, S. K. (2023). Interplay of gut microbiota in polycystic ovarian syndrome: Role of gut microbiota, mechanistic pathways and potential treatment strategies. Pharmaceuticals, 16(2). https://doi.org/10.3390/ph16020197

da Silva, T. R., Marchesan, L. B., Rampelotto, P. H., Longo, L., de Oliveira, T. F., Landberg, R., de Mello, V., & Spritzer, P. M. (2024). Gut microbiota and gut-derived metabolites are altered and associated with dietary intake in women with polycystic ovary syndrome. Journal of Ovarian Research, 17(1), 232. https://doi.org/10.1186/s13048-024-01550-w

Deer, E., et al. (2025). The role of mitochondrial dysfunction and oxidative stress in PCOS. International Journal of Molecular Sciences, 26(13), 6439. https://doi.org/10.3390/ijms26136439

Deng, H., Chen, Y., Xing, J., Zhang, N., & Xu, L. (2024). Systematic low-grade chronic inflammation and intrinsic mechanisms in polycystic ovary syndrome. Frontiers in Immunology, 15, 1470283. https://doi.org/10.3389/fimmu.2024.1470283

Dharani, V., Nishu, S., & Hariprasath, L. (2025). PCOS and genetics: Exploring the heterogeneous role of potential genes in ovarian dysfunction, a hallmark of PCOS—A review. Reproductive Biology, 25(2), 101017. https://doi.org/10.1016/j.repbio.2025.101017

Dokras, A. (2025). Polycystic ovary syndrome in 2025—Insights and innovations. Fertility and Sterility, 124(5 Pt 2), 907–909. https://doi.org/10.1016/j.fertnstert.2025.09.025

Dokras, A., Luque-Ramírez, M., & Escobar-Morreale, H. F. (2025). Polycystic ovary syndrome: Origins and implications: Long-term health outcomes in polycystic ovary syndrome. Reproduction, 170(2). https://doi.org/10.1530/REP-25-0118

Dutta, S., Sengupta, P., Rao, S., Elgarawany, G. E., Samrot, A. V., Rosas, I. M., & Roychoudhury, S. (2025). Targeting polycystic ovary syndrome (PCOS) pathophysiology with flavonoids: From adipokine-cytokine crosstalk to insulin resistance and reproductive dysfunctions. Pharmaceuticals, 18(10), 1575. https://doi.org/10.3390/ph18101575

Edepli, B. G., & Yaba, A. (2026). Molecular mechanisms of ovarian fibrosis. Molecular Human Reproduction, 32(1), gaaf058. https://doi.org/10.1093/molehr/gaaf058

Espinoza Morales, D. I., Valenzuela Gallardo, J., Baltazar Beltrán, M. P., Estrada Salas, C. M., Zazueta Cárdenas, A., & Lugo-Machado, J. A. (2025). Síndrome de ovario poliquístico y trastornos mentales: revisión paraguas. Ginecología y Obstetricia de México, 93(6), 221–239. https://doi.org/10.24245/gom.v93i6.10162

Ethirajulu, A., Alkasabera, A., Onyali, C. B., Anim-Koranteng, C., Shah, H. E., Bhawnani, N., & Mostafa, J. A. (2021). Insulin resistance, hyperandrogenism, and its associated symptoms are the precipitating factors for depression in women with polycystic ovarian syndrome. Cureus, 13(9), e18013. https://doi.org/10.7759/cureus.18013

Fahs, D., Nassar, A. H., Tawil, A., Nimer, H., Abiad, M., Ismail, H., & El-Mallah, C. (2023). Polycystic ovary syndrome: Pathophysiology and controversies in diagnosis. Diagnostics, 13(9), 1559. https://doi.org/10.3390/diagnostics13091559

Forslund, M., Melin, J., Stener-Victorin, E., Hirschberg, A. L., Teede, H., Vanky, E., & Piltonen, T. (2024). International evidence-based guideline on assessment and management of PCOS: A Nordic perspective. Acta Obstetricia et Gynecologica Scandinavica, 103(1), 7–12. https://doi.org/10.1111/aogs.14725

Gao, Y., et al. (2023). Oxidative stress and mitochondrial dysfunction of granulosa cells in polycystic ovarian syndrome. Frontiers in Endocrinology, 14, 1222286. https://doi.org/10.3389/fendo.2023.1222286

García-Sáenz, M. R., Lobaton-Ginsberg, M., Ramírez-Rentería, C., López-Juárez, N., Saucedo, R., Valencia-Ortega, J., & Ferreira-Hermosillo, A. (2023). Hirsutism and polycystic ovarian morphology are the most frequent components of polycystic ovary syndrome in women with type 1 diabetes. Archives of Medical Research, 54(7), 102895. https://doi.org/10.1016/j.arcmed.2023.102895

Ghafari, A., Maftoohi, M., Eslami Samarin, M., Barani, S., Banimohammad, M., & Samie, R. (2025). The last update on polycystic ovary syndrome (PCOS), diagnosis criteria, and novel treatment. Endocrine and Metabolic Science, 17, 100228. https://doi.org/10.1016/j.endmts.2025.100228

Gu, M., Wang, Y., & Yu, Y. (2024). Ovarian fibrosis: Molecular mechanisms and potential therapeutic targets. Journal of Ovarian Research, 17(1), 139. https://doi.org/10.1186/s13048-024-01448-7

Hajam, Y. A., Rather, H. A., Neelam, Kumar, R., Basheer, M., & Reshi, M. S. (2024). A review on critical appraisal and pathogenesis of polycystic ovarian syndrome. Endocrine and Metabolic Science, 14, 100162. https://doi.org/10.1016/j.endmts.2024.100162

Heidarzadehpilehrood, R., Pirhoushiaran, M., Abdollahzadeh, R., Binti Osman, M., Sakinah, M., Nordin, N., & Abdul Hamid, H. (2022). A review on polymorphism studies: Candidate susceptibility genes for polycystic ovary syndrome (PCOS) and infertility. Genes, 13(2). https://doi.org/10.3390/genes13020302

Hofmann, K., Singer, S., Theis, S., Dionysopoulou, A., Schiestl, L., Degirmenci, Y., Hasenburg, A., Schwab, R., & Skala, C. (2025). Mental state and health-related quality of life in patients with polycystic ovary syndrome under metformin therapy—A prospective study. Journal of Psychosomatic Obstetrics & Gynecology, 46(1), 2516669. https://doi.org/10.1080/0167482X.2025.2516669

Hussein, R. S., Dayel, S. B., & Abahussein, O. (2024). Polycystic ovary syndrome and reproductive health: A comprehensive review. Clinical and Experimental Obstetrics & Gynecology, 51(12). https://doi.org/10.31083/j.ceog5112269

Islam, H., Masud, J., Islam, Y. N., & Haque, F. K. M. (2022). An update on polycystic ovary syndrome: A review of the current state of knowledge in diagnosis, genetic etiology, and emerging treatment options. Women’s Health, 18, 17455057221117966. https://doi.org/10.1177/17455057221117966

Jakubowska-Kowal, K. M., Skrzynska, K. J., & Gawlik-Starzyk, A. M. (2024). Prevalence and diagnosis of polycystic ovary syndrome (PCOS) in adolescents—What’s new in 2023? Systematic review. Ginekologia Polska, 95(8), 643–649. https://doi.org/10.5603/gpl.98849

Jannink, T. (2024). P-471: Anxiety, depression, and body image among infertile women with and without polycystic ovary syndrome. Human Reproduction, 39(Supplement_1). https://doi.org/10.1093/humrep/deae108.124

Joham, A. E., Piltonen, T., Lujan, M. E., Kiconco, S., & Tay, C. T. (2022). Challenges in diagnosis and understanding of natural history of polycystic ovary syndrome. Clinical Endocrinology, 97(2), 165–173. https://doi.org/10.1111/cen.14757

Johnson, J.-E., Daley, D., Tarta, C., & Stanciu, P. I. (2023). Risk of endometrial cancer in patients with polycystic ovarian syndrome: A meta-analysis. Oncology Letters, 25(4), 168. https://doi.org/10.3892/ol.2023.13754

Kamar Bashah, N. A., Hamid, A. A., Adam, S. H., Jaffar, F. H. F., Abd Rahman, I. Z., & Mokhtar, M. H. (2025). Role of AMP-activated protein kinase (AMPK) in female reproduction: A review. International Journal of Molecular Sciences, 26(14), 6833. https://doi.org/10.3390/ijms26146833

Kaur, M., Singh, S., Beri, A., & Kaur, A. (2025). Exploring genotype-phenotype correlation of FSHR polymorphisms in polycystic ovary syndrome. BMC Endocrine Disorders, 25(1), 239. https://doi.org/10.1186/s12902-025-01979-0

Khan, M. I., Haider, S., Kundi, F. K., Ayub, A., Shaukat, F., Mehmood, M., Qureshi, M. A., Khan, M. S., & Khan, R. (2025). Enhanced polycystic ovary syndrome screening: Incorporating population- and symptom-specific scales into a validated questionnaire and assessment of the syndrome’s associated factors: An analytical cross-sectional study. Middle East Fertility Society Journal, 30(1). https://doi.org/10.1186/s43043-025-00248-3

Li, Y., Zhang, J., Zheng, X., Lu, W., Guo, J., Chen, F., & Liu, C. (2024). Depression, anxiety and self-esteem in adolescent girls with polycystic ovary syndrome: A systematic review and meta-analysis. Frontiers in Endocrinology, 15, 1399580. https://doi.org/10.3389/fendo.2024.1399580

Liu, H., Jin, L., Wang, X., Shi, J., He, Y., Sun, N., & Yang, F. (2025). Reactive oxygen species in polycystic ovary syndrome: Mechanistic insights into pathogenesis and therapeutic opportunities. Redox Biology, 103776. https://doi.org/10.1016/j.redox.2025.103776

Liu, Y., Zhu, J., Yang, Y., Chen, Z., Zhou, Y., Fei, W., Zhang, X., & Zheng, Y. (2025). Extracellular matrix dysregulation in PCOS: Pathogenesis, therapeutic strategies, and innovative technologies. Journal of Biological Engineering, 19(1), 61. https://doi.org/10.1186/s13036-025-00533-9

Mei, Y., Li, W., Wang, B., Chen, Z., Wu, X., Lin, Y., & Wang, M. (2025). Gut microbiota: An emerging target connecting polycystic ovarian syndrome and insulin resistance. Frontiers in Cellular and Infection Microbiology, 15, 1508893. https://doi.org/10.3389/fcimb.2025.1508893

Moka, M. K., Sriram, D. K., & George, M. (2025). Recent advances in individualized clinical strategies for polycystic ovary syndrome: Evidence from clinical trials and emerging pharmacotherapies. Clinical Therapeutics, 47(2), 158–167. https://doi.org/10.1016/j.clinthera.2024.11.015

Monash University. (2023). International evidence-based guideline for the assessment and management of polycystic ovary syndrome 2023. https://www.monash.edu/__data/assets/pdf_file/0003/3371133/PCOS-Guideline-Summary-2023.pdf

Moore, A. M. (2025). Neuroendocrine mechanisms responsible for elevated gonadotrophin-releasing hormone and luteinising hormone pulses in polycystic ovary syndrome. Journal of Neuroendocrinology, 37(8), e70028. https://doi.org/10.1111/jne.70028

Moran, L. J. (2025). Advances in cardiometabolic outcomes in polycystic ovary syndrome. Nature Reviews Endocrinology, 21(2), 67–68. https://doi.org/10.1038/s41574-024-01072-x

Moreno-Ruiz, L. A., Madrid-Miller, A., Necoechea-Osuna, Y., & Vega-Gutiérrez, J. J. (2024). Ovarios poliquísticos como factor de riesgo cardiometabólico para hipertensión arterial. Cardiovascular and Metabolic Science, 35(S1), s25–s27. https://dx.doi.org/10.35366/115056

Myerson, M. L., Paparodis, R. D., Block, R. C., Karalis, D. G., Mintz, G., Brinton, E. A., & Wild, R. (2024). Polycystic ovary syndrome: A review of diagnosis and management, with special focus on atherosclerotic cardiovascular disease prevention. Journal of Clinical Lipidology, 18(4), e488–e500. https://doi.org/10.1016/j.jacl.2024.04.131

Neven, A. C. H., Forslund, M., Ranasinha, S., Sethi, P., Dhungana, R. R., Mousa, A., Tay, C. T., Teede, H., & Boyle, J. A. (2026). Prevalence of polycystic ovary syndrome: A global and regional systematic review and meta-analysis. Human Reproduction Update. https://doi.org/10.1093/humupd/dmaf030

Noguchi, H., Iwasa, T., Iwase, A., Kanasaki, H., Kimura, F., Kugu, K., Saito, K., Baba, T., Hara, T., & Matsuzaki, T. (2024). Cut-off value for anti-Müllerian hormone in the diagnostic criteria for polycystic ovary syndrome in the Japanese population. Journal of Obstetrics and Gynaecology Research, 50(8), 1368–1382. https://doi.org/10.1111/jog.15972

Park, J.-E., Park, H.-Y., Kim, Y.-S., & Park, M. (2024). The role of diet, additives, and antibiotics in metabolic endotoxemia and chronic diseases. Metabolites, 14(12). https://doi.org/10.3390/metabo14120704

Parker, J., & Hitch, V. (2025). New challenges and perspectives in polycystic ovary syndrome. Journal of Clinical Medicine, 14(24), 8867. https://doi.org/10.3390/jcm14248867

Parker, J., Briden, L., & Gersh, F. L. (2025). Recognizing the role of insulin resistance in polycystic ovary syndrome: A paradigm shift from a glucose-centric approach to an insulin-centric model. Journal of Clinical Medicine, 14(12), 4021. https://doi.org/10.3390/jcm14124021

Prosperi, S., & Chiarelli, F. (2025). Insulin resistance, metabolic syndrome and polycystic ovaries: An intriguing conundrum. Frontiers in Endocrinology, 16, 1669716. https://doi.org/10.3389/fendo.2025.1669716

Qi, Y.-B., Yi, P., & Fu, X.-H. (2025). Research progress on insulin resistance in polycystic ovary syndrome. Reproductive and Developmental Medicine, 9(2), 119–128. http://dx.doi.org/10.1097/RD9.0000000000000131

Rambaran, N., & Islam, M. S. (2025). Decoding androgen excess in polycystic ovary syndrome: Roles of insulin resistance and other key intraovarian and systemic factors. World Journal of Diabetes, 16(7), 108789. https://dx.doi.org/10.4239/wjd.v16.i7.108789

Rehmat, L., Zaki, S., Khan, H. N., Khan, U. I., & Rehman, R. (2025). Anti-Müllerian hormone gene polymorphism in polycystic ovary syndrome: A pilot study. Pakistan Journal of Medical Sciences, 41(9), 2646–2651. https://doi.org/10.12669/pjms.41.9.12104

Rivera-Castro, M. E., Pastelín, C. F., Bravo-Benítez, J., & Morán, C. (2023). Organization of the subdiaphragmatic vagus nerve and its connection with the celiac plexus and the ovaries in the female rat. Brain Sciences, 13(7), 1032. https://doi.org/10.3390/brainsci13071032

Robeva, R., Mehandjiev, T., Dimitrov, R., Hranov, Y., Andonova, S., Mladenova, M., Elenkova, A., Hadjidekov, G., & Zacharieva, S. (2026). AMH in PCOS and beyond—Rare case series. Diagnostics, 16(1). https://doi.org/10.3390/diagnostics16010123

Rojas Alarcón, A. P., & Walther Sánchez, C. (2026). Prevalencia del síndrome de ovario poliquístico en mujeres de Latinoamérica: Una revisión sistemática [Tesis de médico cirujano, Universidad Peruana de Ciencias Aplicadas]. https://repositorioacademico.upc.edu.pe/handle/10757/688841

Secretaría de Salud. (2024). 096. Síndrome de ovario poliquístico, común entre las mujeres mexicanas. gob.mx. https://www.gob.mx/salud/prensa/096-sindrome-de-ovario-poliquistico-comun-entre-las-mujeres-mexicanas

Senthilkumar, H., & Arumugam, M. (2025). Gut microbiota: A hidden player in polycystic ovary syndrome. Journal of Translational Medicine, 23(1), 443. https://doi.org/10.1186/s12967-025-06315-7

Shahmoradi, L., Azadbakht, L., Farzi, J., Rostam Niakan Kalhori, S., Banaye Yazdipour, A., & Solat, F. (2024). Nutritional management recommendation systems in polycystic ovary syndrome: A systematic review. BMC Women’s Health, 24(1), 234. https://doi.org/10.1186/s12905-024-03074-3

Shi, N., & Ma, H.-B. (2022). Global trends in polycystic ovary syndrome research: A 10-year bibliometric analysis. Frontiers in Endocrinology, 13, 1027945. https://doi.org/10.3389/fendo.2022.1027945

Shirazi, F. K. H., Khodamoradi, Z., & Jeddi, M. (2021). Insulin resistance and high molecular weight adiponectin in obese and non-obese patients with polycystic ovarian syndrome (PCOS). BMC Endocrine Disorders, 21(1), 45. https://doi.org/10.1186/s12902-021-00710-z

Shruthi, S., Lakshmi, G., T. S., M., & Washington, J. K. (2025). Prevalence and predictors of metabolic syndrome in women with polycystic ovarian syndrome: A cross-sectional study. Cureus, 17(12), e98869. https://doi.org/10.7759/cureus.98869

Shukla, A., Rasquin, L. I., & Anastasopoulou, C. (2025). Polycystic ovarian syndrome. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/sites/books/NBK459251/

Sikonja, J., Jensterle, M., & Janež, A. (2023). Insulin metabolism in polycystic ovary syndrome: Secretion, signaling, and clearance. International Journal of Molecular Sciences, 24(4), 3934. https://doi.org/10.3390/ijms24043934

Silva, E. L., Lane, K. J., Cheng, J. J., Popp, Z., van Loenen, B. D., Coull, B., Hart, J. E., James-Todd, T., & Mahalingaiah, S. (2025). Polycystic ovary syndrome underdiagnosis patterns by individual-level and spatial social vulnerability measures. The Journal of Clinical Endocrinology & Metabolism, 110(6), 1657–1666. https://doi.org/10.1210/clinem/dgae705

Singh, D. (2024). Nanotechnology-based diagnostic approaches for early detection and monitoring of polycystic ovary syndrome (PCOS). Current Analytical Chemistry, 20. https://doi.org/10.2174/0115734110311450240612051821

Singh, S., Pal, N., Shubham, S., Sarma, D. K., Verma, V., Marotta, F., & Kumar, M. (2023). Polycystic ovary syndrome: Etiology, current management, and future therapeutics. Journal of Clinical Medicine, 12(4), 1454. https://doi.org/10.3390/jcm12041454

Spritzer, P. M., Salazar Santos, G. G., Munevar Vega, M. L., Chedraui, P., Pilnik, S., Camero Lascano, A., Belardo, A., Elizalde Cremonte, A., Vivas Ramírez, A., Rosas Balán, A., Barragán, A. M., Gómez Quintero, A. M., Camargo Rodríguez, C. A., Buitrago, D. A., Barón Castañeda, G., Rossi, G., de la Parra, I., Montes Suárez, I. D., Michel Vergara, J. A., … Manzur, A. (2025). Evaluation of the evidence-based practices for the management of PCOS in the Latin America context: The consensus of the Latin American Association of Gynecological Endocrinology (ALEG). Gynecological Endocrinology, 41(1), 2456578. https://doi.org/10.1080/09513590.2025.2456578

Stener-Victorin, E., Teede, H., Norman, R. J., Legro, R. S., Goodarzi, M. O., Dokras, A., Laven, J., Hoeger, K., & Piltonen, T. T. (2024). Polycystic ovary syndrome. Nature Reviews Disease Primers, 10(1). https://doi.org/10.1038/s41572-024-00511-3

Su, P., Chen, C., & Sun, Y. (2025). Physiopathology of polycystic ovary syndrome in endocrinology, metabolism and inflammation. Journal of Ovarian Research, 18(1), 34. https://doi.org/10.1186/s13048-025-01621-6

Suliman, O., Al Sebaa, N., Alofy, L., Mahjoub, E., & Alhussain, Z. (2025). The effectiveness of diet and exercise in treating polycystic ovary syndrome: A systematic review. Journal of Advances in Medicine and Medical Research, 37(8), 211–221. https://doi.org/10.9734/jammr/2025/v37i85917

Sun, J., Wang, M., & Kan, Z. (2024). Causal relationship between gut microbiota and polycystic ovary syndrome: A literature review and Mendelian randomization study. Frontiers in Endocrinology, 15, 1280983. https://doi.org/10.3389/fendo.2024.1280983

Sun, Y., Gao, S., Ye, C., & Zhao, W. (2023). Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications. Frontiers in Cellular and Infection Microbiology, 13, 1142041. https://doi.org/10.3389/fcimb.2023.1142041

Taşkin, E., & Eroğlu, S. (2025). Investigation of associations between polycystic ovary syndrome and INSR gene polymorphisms rs2059806 and rs2252673. Revista da Associação Médica Brasileira, 71(1), e20241056. https://doi.org/10.1590/1806-9282.20241056

Tay, C. T., Mousa, A., Vyas, A., Pattuwage, L., Ramezani Tehrani, F., & Teede, H. (2024). 2023 international evidence-based polycystic ovary syndrome guideline update: Insights from a systematic review and meta-analysis on elevated clinical cardiovascular disease in polycystic ovary syndrome. Journal of the American Heart Association, 13(16), e033572. https://doi.org/10.1161/JAHA.123.033572

Teede, H. J., Mousa, A., Tay, C. T., Costello, M. F., Brennan, L., Norman, R. J., ... & Moran, L. (2024). Summary of the 2023 international evidence‐based guideline for the assessment and management of polycystic ovary syndrome: an Australian perspective. Medical Journal of Australia, 221(7), 389-395. https://doi.org/10.5694/mja2.52432

Vieyra, E., Silva, C.-C., Linares, R., Rosas, G., Espinoza, J.-A., Chaparro, A., Calderón, R., de la Peña, B., & Morales-Ledesma, L. (2025). The hypothalamic nuclei implicated in the regulation of polycystic ovary syndrome: A review of its clinical, metabolic, and endocrine aspects. Molecules, 30(16), 3407. https://doi.org/10.3390/molecules30163407

Villalobos, A., Suárez-López, L., de la Vara-Salazar, E., Hubert, C., Hernández, B., Varela-Chávez, Y., Torres-Chaires, M. M., & Ávila-Burgos, L. (2024). Servicios de salud sexual y reproductiva en adolescentes. Salud Pública de México, 66, 479–487. https://doi.org/10.21149/15834

Voros, C., Mavrogianni, D., Minaoglou, A., Karakasis, A., Papahliou, A. M., Topalis, V., … Daskalakis, G. (2024). Nitrate–nitrite–nitric oxide pathway, oxidative stress, and fertility outcomes in morbidly obese women following bariatric surgery: A systematic review. Biomedicines, 13(1), 64. https://doi.org/10.3390/biomedicines13010064

Wang, K., & Li, Y. (2023). Signaling pathways and targeted therapeutic strategies for polycystic ovary syndrome. Frontiers in Endocrinology, 14, 1191759. https://doi.org/10.3389/fendo.2023.1191759

Wang, L., Liu, K., Wang, G., & Yang, L. (2025). Effects of exercise interventions on women with polycystic ovary syndrome: A systematic review and meta-analysis. Nursing & Health Sciences, 27(3), e70209. https://doi.org/10.1111/nhs.70209

World Health Organization. (2026, January 22). Polycystic ovary syndrome. https://www.who.int/es/news-room/fact-sheets/detail/polycystic-ovary-syndrome

Xu, H., Feng, G., Alpadi, K., Han, Y., Yang, R., Chen, L., Li, R., & Qiao, J. (2022). A model for predicting polycystic ovary syndrome using serum AMH, menstrual cycle length, body mass index and serum androstenedione in Chinese reproductive aged population: A retrospective cohort study. Frontiers in Endocrinology, 13, 821368. https://doi.org/10.3389/fendo.2022.821368

Yan, H., et al. (2024). Oxidative stress and energy metabolism abnormalities in polycystic ovary syndrome: From mechanisms to therapeutic strategies. Reproductive Biology and Endocrinology, 22, 132. https://doi.org/10.1186/s12958-024-01337-0

Yan, X., Ma, D., et al. (2025). The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome. Endocrine Connections, 14(7), e250186. https://doi.org/10.1530/EC-25-0186

Yasmin, A., Roychoudhury, S., Paul Choudhury, A., Ahmed, A. B. F., Dutta, S., Mottola, F., Verma, V., Kalita, J. C., Kumar, D., Sengupta, P., & Kolesarova, A. (2022). Polycystic ovary syndrome: An updated overview foregrounding impacts of ethnicities and geographic variations. Life, 12(12). https://doi.org/10.3390/life12121974

Zhang, C., & Yu, J. (2024). FTO gene polymorphism and susceptibility to polycystic ovary syndrome: A meta-analysis. Journal of Obstetrics and Gynaecology Research, 50(9), 1703–1712. https://doi.org/10.1111/jog.16047

Zhang, Q., Yang, Z., Ou, X., Zhang, M., Qin, X., & Wu, G. (2025). The role of immunity in insulin resistance in patients with polycystic ovary syndrome. Frontiers in Endocrinology, 15, 1464561. https://doi.org/10.3389/fendo.2024.1464561

Zhang, Y., Yang, K., Fan, T., Zheng, D., & Liu, H. (2025). Diagnosis and treatment of adolescent polycystic ovary syndrome: A review. International Journal of Women’s Health, 17, 459–474. https://doi.org/10.2147/IJWH.S506498

Zhao, H., Zhang, J., Cheng, X., Nie, X., & He, B. (2023). Insulin resistance in polycystic ovary syndrome across various tissues: An updated review of pathogenesis, evaluation, and treatment. Journal of Ovarian Research, 16(1), 9. https://doi.org/10.1186/s13048-022-01091-0

Zhao, M., Chen, D., Hu, X., Xie, C., Xu, L., & Zhou, F. (2025). Gut-ovary axis in polycystic ovary syndrome: Mechanistic insights and gut microbiota-targeted therapeutic strategies. Frontiers in Endocrinology, 16, 1684492. https://doi.org/10.3389/fendo.2025.1684492

Zhao, S. (2025). Current status of research on improving polycystic ovary syndrome through dietary interventions and exercise. Theoretical and Natural Science, 110(1), 57–64. https://doi.org/10.54254/2753-8818/2025.AU22999

Zhu, T., & Goodarzi, M. O. (2022). Causes and consequences of polycystic ovary syndrome: Insights from Mendelian randomization. The Journal of Clinical Endocrinology & Metabolism, 107(3), e899–e911. https://doi.org/10.1210/clinem/dgab757

Zhu, R., Yang, L., Li, Y., Wang, X., Wang, Y., Wang, J., & Liu, J. (2025). TXNIP participates in the pathogenesis of PCOS by regulating glycolysis in granulosa cells. Biochemical and Biophysical Research Communications, 775, 152149. https://doi.org/10.1016/j.bbrc.2025.152149

Published

2026-04-15

How to Cite

Moreno Hernández, K. Y., Morales Rojas, H. A., Cruz Trejo, D., & Cosme Herrera, Y. I. (2026). Design of a Screening Tool for the Early Detection of Polycystic Ovary Syndrome (PCOS). MENTOR Revista De investigación Educativa Y Deportiva , 5(2), 201–229. https://doi.org/10.56200/mentor.v5i2.12364

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Review Articles

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