Dietary supplements and physical exercise in polycystic ovary syndrome
DOI:
https://doi.org/10.56200/mried.v4i12.9284Keywords:
Dietary supplements, Physical exercise, Polycystic ovary syndromeAbstract
Polycystic ovary syndrome (PCOS) is a multifactorial endocrine-metabolic disorder that significantly affects the reproductive, metabolic, and psychological health of women in their reproductive stage. This narrative review studied the effects of the consumption of dietary supplements and the practice of physical exercise in the prevention and/or treatment of PCOS, emphasizing the management of its symptoms. The research encompassed studies from the electronic repositories MEDLINE (PubMed), the Cochrane Central Register of Controlled Trials, and the Web of Science. 14 studies published from 2014 to 2024 were selected, including systematic reviews, meta-analyses, narrative reviews, clinical guidelines, and a clinical trial. The main findings indicate that regular exercise enhances insulin sensitivity and hormonal regulation. Supplements such as inositol, omega-3, vitamin D, and curcumin have shown potential efficacy in alleviating PCOS symptoms and improving the metabolism of these women. To conclude, the evidence suggests that lifestyle modifications including physical exercise and some nutritional supplements can reduce symptoms and improve metabolic and reproductive parameters, particularly in women with excess weight and insulin resistance. However, methodological diversity requires that the findings be interpreted with caution.
Downloads
Metrics
References
Abraham Gnanadass, S., Divakar Prabhu, Y., & Valsala Gopalakrishnan, A. (2021). Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): An update. Archives of Gynecology and Obstetrics, 303(3), 631–643. https://doi.org/10.1007/s00404-020-05951-2 DOI: https://doi.org/10.1007/s00404-020-05951-2
Alesi, S., Ee, C., Moran, L. J., Rao, V., & Mousa, A. (2022). Nutritional Supplements and Complementary Therapies in Polycystic Ovary Syndrome. Advances in Nutrition, 13(4), 1243–1266. https://doi.org/10.1093/advances/nmab141 DOI: https://doi.org/10.1093/advances/nmab141
Arietaleanizbeaskoa, M. S., Sancho, A., Olazabal, I., Moreno, C., Gil, E., Garcia-Alvarez, A., Mendizabal, N., de la Fuente, I., Dominguez, S., Pablo, S., & Grandes, G. (2020). Effectiveness of physical exercise for people with chronic diseases: The EFIKRONIK study protocol for a hybrid, clinical and implementation randomized trial. BMC Family Practice, 21, 227. https://doi.org/10.1186/s12875-020-01298-4 DOI: https://doi.org/10.1186/s12875-020-01298-4
Ashkar, F., Eftekhari, M. H., Tanideh, N., Koohpeyma, F., Mokhtari, M., Irajie, C., & Iraji, A. (2020). Effect of hydroalcoholic extract of Berberis integerrima and resveratrol on ovarian morphology and biochemical parameters in Letrozole-induced polycystic ovary syndrome rat model: An experimental study. International Journal of Reproductive Biomedicine, 18(8), 637–650. https://doi.org/10.18502/ijrm.v13i8.7505 DOI: https://doi.org/10.18502/ijrm.v13i8.7505
Berger, M. M., Shenkin, A., Schweinlin, A., Amrein, K., Augsburger, M., Hans-Konrad Biesalski, Bischoff, S. C., Casaer, M. P., Kursat Gundogan, Lepp, H.-L., Man, Muscogiuri, G., Pietka, M., Pironi, L., Serge Rezzi, & Cuerda, C. (2022). ESPEN micronutrient guideline. Clinical Nutrition, 41(6), 1357–1424. https://doi.org/10.1016/j.clnu.2022.02.015 DOI: https://doi.org/10.1016/j.clnu.2022.02.015
Calcaterra, V., Verduci, E., Cena, H., Magenes, V. C., Todisco, C. F., Tenuta, E., Gregorio, C., De Giuseppe, R., Bosetti, A., Di Profio, E., & Zuccotti, G. (2021). Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity: The Role of Nutrition Therapy and Food Supplements as a Strategy to Protect Fertility. Nutrients, 13(6), Article 6. https://doi.org/10.3390/nu13061848 DOI: https://doi.org/10.3390/nu13061848
Cheema, B. S., Vizza, L., & Swaraj, S. (2014). Progressive resistance training in polycystic ovary syndrome: Can pumping iron improve clinical outcomes? Sports Medicine (Auckland, N.Z.), 44(9), 1197–1207. https://doi.org/10.1007/s40279-014-0206-6 DOI: https://doi.org/10.1007/s40279-014-0206-6
Chen, W., & Pang, Y. (2021). Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites. Metabolites, 11(12), Article 12. https://doi.org/10.3390/metabo11120869 DOI: https://doi.org/10.3390/metabo11120869
Costello, M. F., Misso, M. L., Balen, A., Boyle, J., Devoto, L., Garad, R. M., Hart, R., Johnson, L., Jordan, C., Legro, R. S., Norman, R. J., Mocanu, E., Qiao, J., Rodgers, R. J., Rombauts, L., Tassone, E. C., Thangaratinam, S., Vanky, E., Teede, H. J., & International PCOS Network. (2019). Evidence summaries and recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome: Assessment and treatment of infertility. Human Reproduction Open, 2019(1), hoy021. https://doi.org/10.1093/hropen/hoy021 DOI: https://doi.org/10.1093/hropen/hoy021
De Araújo Medeiros Dias, D., Silva, I. L., & Jovita, M. C. (2022). Síndrome do Ovário Policístico e Vitamina D. Research Society And Development, 11(11), e521111131907. https://doi.org/10.33448/rsd-v11i11.31907 DOI: https://doi.org/10.33448/rsd-v11i11.31907
Dobbie, L. J., Pittam, B., Zhao, S. S., Alam, U., Hydes, T. J., Barber, T. M., & Cuthbertson, D. J. (2023). Childhood, adolescent, and adulthood adiposity are associated with risk of PCOS: A Mendelian randomization study with meta-analysis. Human Reproduction (Oxford, England), 38(6), 1168–1182. https://doi.org/10.1093/humrep/dead053 DOI: https://doi.org/10.1093/humrep/dead053
Fatima, K., Jamil, Z., Faheem, S., Adnan, A., Javaid, S. S., Naeem, H., Mohiuddin, N., Sajid, A., & Ochani, S. (2023). Effects of myo-inositol vs. metformin on hormonal and metabolic parameters in women with PCOS: A meta-analysis. Irish Journal of Medical Science, 192(6), 2801–2808. https://doi.org/10.1007/s11845-023-03388-5 DOI: https://doi.org/10.1007/s11845-023-03388-5
Febres Balestrini, F. (2016). Etiología del síndrome de ovario poliquístico. Revista de Obstetricia y Ginecología de Venezuela, 76, S5–S9.
García-Sáenz, M. R., Ferreira-Hermosillo, A., & Miry Lobaton-Ginsberg. (2022). Citocinas proinflamatorias en el síndrome de ovario poliquístico. Revista Médica Del Instituto Mexicano Del Seguro Social, 60(5), 569. https://doi.org/10396056/pdf/04435117-60-5-569
Greff, D., Juhász, A. E., Váncsa, S., Váradi, A., Sipos, Z., Szinte, J., Park, S., Hegyi, P., Nyirády, P., Ács, N., Várbíró, S., & Horváth, E. M. (2023). Inositol is an effective and safe treatment in polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. Reproductive Biology and Endocrinology, 21(1), 10. https://doi.org/10.1186/s12958-023-01055-z DOI: https://doi.org/10.1186/s12958-023-01055-z
Gu, Y., Zhou, G., Zhou, F., Wu, Q., Ma, C., Zhang, Y., Ding, J., & Hua, K. (2022). Life Modifications and PCOS: Old Story But New Tales. Frontiers in Endocrinology, 13, 808898. https://doi.org/10.3389/fendo.2022.808898 DOI: https://doi.org/10.3389/fendo.2022.808898
Hafizi Moori, M., Nosratabadi, S., Yazdi, N., Kasraei, R., Abbasi Senjedary, Z., & Hatami, R. (2023). The Effect of Exercise on Inflammatory Markers in PCOS Women: A Systematic Review and Meta-Analysis of Randomized Trials. International Journal of Clinical Practice, 2023, 3924018. https://doi.org/10.1155/2023/3924018 DOI: https://doi.org/10.1155/2023/3924018
Kiani, A. K., Donato, K., Dhuli, K., Stuppia, L., & Bertelli, M. (2022). Dietary supplements for polycystic ovary syndrome. Journal of Preventive Medicine and Hygiene, 63(2S3), Article 2S3. https://doi.org/10.15167/2421-4248/jpmh2022.63.2S3.2762
Park, S. J., Kim, T.-H., & Oh, S. (2020). Immediate Effects of Tibialis Anterior and Calf Muscle Taping on Center of Pressure Excursion in Chronic Stroke Patients: A Cross-Over Study. International Journal of Environmental Research and Public Health, 17(11), 4109. https://doi.org/10.3390/ijerph17114109 DOI: https://doi.org/10.3390/ijerph17114109
Patten, R. K., Boyle, R. A., Moholdt, T., Kiel, I., Hopkins, W. G., Harrison, C. L., & Stepto, N. K. (2020). Exercise Interventions in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. Frontiers in Physiology, 11, 606. https://doi.org/10.3389/fphys.2020.00606 DOI: https://doi.org/10.3389/fphys.2020.00606
Petersen, A., & Pedersen, B. (2005). The anti-inflammatory effect of exercise. Journal of Applied Physiology, 98(4), 1154–1162. https://doi.org/10.1152/japplphysiol.00164.2004 DOI: https://doi.org/10.1152/japplphysiol.00164.2004
Sharma, P., Bhatia, K., Singh Kapoor, H., Kaur, B., & Khetarpal, P. (2023). Genetic variants of metabolism and inflammatory pathways, and PCOS risk -Systematic review, meta-analysis, and in-silico analysis. Gene, 888, 147796. https://doi.org/10.1016/j.gene.2023.147796 DOI: https://doi.org/10.1016/j.gene.2023.147796
Singh, J. R., Jain, A., Wadhwa, N., H.R., T., & Ahirwar, A. K. (2022). La resistencia a la insulina como factor etiológico en el síndrome del ovario poliquístico: un estudio de casos y controles. Advances in Laboratory Medicine / Avances En Medicina de Laboratorio, 3(2), 205–209. https://doi.org/10.1515/almed-2022-0050 DOI: https://doi.org/10.1515/almed-2022-0050
Stener-Victorin, E., Teede, H., Norman, R. J., Legro, R., Goodarzi, M. O., Dokras, A., Laven, J., Hoeger, K., & Piltonen, T. T. (2024). Polycystic ovary syndrome. Nature Reviews. Disease Primers, 10(1), 27. https://doi.org/10.1038/s41572-024-00511-3 DOI: https://doi.org/10.1038/s41572-024-00511-3
Stepto, N. K., Patten, R. K., Tassone, E. C., Misso, M. L., Brennan, L., Boyle, J., Boyle, R. A., Harrison, C. L., Hirschberg, A. L., Marsh, K., Moreno-Asso, A., Redman, L., Thondan, M., Wijeyaratne, C., Teede, H. J., & Moran, L. J. (2019). Exercise Recommendations for Women with Polycystic Ovary Syndrome: Is the Evidence Enough?. Sports medicine (Auckland, N.Z.), 49(8), 1143–1157. https://doi.org/10.1007/s40279-019-01133-6 DOI: https://doi.org/10.1007/s40279-019-01133-6
Stevens, S. L. (2021). Fat-Soluble Vitamins. Nursing Clinics of North America, 56(1), 33–45. https://doi.org/10.1016/j.cnur.2020.10.003 DOI: https://doi.org/10.1016/j.cnur.2020.10.003
Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., Piltonen, T., & Norman, Robert. J. (2018). Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertility and sterility, 110(3), 364–379. https://doi.org/10.1016/j.fertnstert.2018.05.004 DOI: https://doi.org/10.1111/cen.13795
Teede, H. J., Tay, C. T., Laven, J., Dokras, A., Moran, L. J., Piltonen, T. T., Costello, M. F., Boivin, J., M Redman, L., A Boyle, J., Norman, R. J., Mousa, A., Joham, A. E., & International PCOS Network. (2023). Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. Fertility and Sterility, 120(4), 767–793. https://doi.org/10.1016/j.fertnstert.2023.07.025 DOI: https://doi.org/10.1097/OGX.0000000000001233
Villanea, C. F. (2018). Síndrome de ovario poliquístico. Revista Médica Sinergia, 3(6), Article 6. https://doi.org/10.31434/rms.v3i6.130 DOI: https://doi.org/10.31434/rms.v3i6.130
Woodward, A., Klonizakis, M., & Broom, D. (2020). Exercise and Polycystic Ovary Syndrome. Advances in Experimental Medicine and Biology, 1228, 123–136. https://doi.org/10.1007/978-981-15-1792-1_8 DOI: https://doi.org/10.1007/978-981-15-1792-1_8
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Stephanie-Marie Cruz-Pierard, Samuel-Olegario Iñiguez-Jiménez, Jonathan-Luis Cruz-Pierard

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.





































+593987341121 Email: rjposso@revistamentor.ec